22



Keep the vial adapter attached to the vial and remove the vial from the well (vial holder).

Be careful not to pull the

vial adapter off the top of the vial.



Connect the pre-filled diluent syringe to the vial adapter by turning clockwise until resistance is felt and the

attachment is secure.

This forms the syringe assembly

(See Figure E).



Slowly push the plunger of the pre-filled diluent syringe all the way in.

This will transfer all of the liquid from

the syringe into the BETASERON vial

(See Figure F)

.

The plunger may return to its original position after

you release it.



Gently swirl the vial to completely dissolve the white powder of BETASERON.

Do not shake.

Shaking and even

gentle mixing can cause foaming of the medicine.

If there is foam, let the vial sit until the foam settles before

using it.



After the powder dissolves, look closely at the solution in the vial.

Do not use the solution if it is cloudy or

contains particles.

It should be clear and colorless.



Do not use cracked or damaged BETASERON vials. If your vial is cracked or damaged, get a new single-use

carton containing a BETASERON vial, pre-filled diluent syringe, vial adapter and 2 alcohol prep pads. Repeat the

steps to prepare your BETASERON dose.



Contact BETAPLUS, the BETASERON patient support program, at 1-800-788-1467 to obtain a replacement

product.